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Generally , Anime refers to Japanese Anime and Animation refers to American  or Other Animation.  But,  Pokemon vs Optimus Prime Between Anime: Pokemon and Animation (Transformers) Optimus Prime,  Pokemon is the most popular Anime.  Pokemon is so famous that it generated around 71 billion dollars in its lifetime.  Transformers is also popular and generated around 5 billion dollars , which is not comparable to the collection of Pokemon.  This can be a measure to compare the Popularity of the shows. Also, Pokemon is considered One of the most viewed Anime of All Time. While on the other side Transformers is famous for its Movie Series. Optimus Prime being The Leader of Autobots is Famous but not as famous as  Pokemon.